Aging is associated with increasing risk factors for cardiovascular disease. Changes in your arteries, such as hardening or cholesterol blockages, contribute to decreased physical activity. In addition, the age-related loss of muscle mass and function, known as sarcopenia, is also attributed to endothelial dysfunction. Decreased nitric oxide (NO) levels contribute to sarcopenia by leading to reduced blood flow and fewer amino acids delivered to skeletal muscles. Taking care of your endothelium is important to stop – or even reverse – this muscle weakening.
What is the endothelium?
The endothelium is a single inner layer of cells that lines every artery in your body. Endothelial cells play a primary role in blood pressure and blood flow regulation by producing nitric oxide (NO), a potent vasodilator. More than 100,000 medical studies in the past twenty years validate its importance and beneficial impact on cellular health.
Endogenous NO is produced by a group of enzymes that convert the amino acid arginine into NO and citrulline. NO then rapidly diffuses into the muscular part of the artery, causing it to relax and increasing the blood flow to every organ. Can you think of any organ that will NOT improve with better circulation?
Evidence indicates that long-term supplementation with only arginine the amount of NO that is produced because arginine activates an enzyme, called arginase, that breaks down the amino acid. As it turns out, citrulline actually inhibits the arginase enzyme, keeping arginine more metabolically available. Additionally, citrulline is better absorbed and utilized when compared with a similar dose of oral arginine. It has been shown that after only one week of citrulline supplementation, the amount of both free arginine and free nitric oxide in the blood is increased. Therefore, citrulline supplementation has a greater ability to improve age-related vascular dysfunction.
Recent evidence suggests that supplementation with both arginine and citrulline combined with exercise training may benefit arteries in all ages. That’s why we recommend Cardiomiracle for everyone. It contains both arginine and citrulline, along with 50 other non-GMO nutrients. It is also free from soy, dairy, gluten, additives, and stimulants such as caffeine. If you use our affiliate code DrT at checkout, you’ll get 15% off on your first purchase.
However, if you don’t like the taste or you don’t want to mess with the powder, you can take citrulline as a pill in our Citrucore, which contains citrulline, grape seed extract, and quercetin. Citrulline supplementation alone improves muscle protein synthesis, muscle mass, and oxygen delivery and improves exercise performance. In fact, researchers noted a positive effect on high-intensity exercise performance in track athletes in as little as 7 days when taking 3 grams of citrulline per day, the recommended dose in Citrucore. So, no matter what your age or workout potential, adding citrulline and arginine to your workout will improve your outcome.
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